منابع مشابه
The Proinsulin C-peptide—A Multirole Model
The C-peptide links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. It then facilitates the intracellular transport, sorting, and proteolytic processing of proinsulin into biologically active insulin in the maturing secretory granules of the beta cells. These manifold fu...
متن کاملProinsulin C-peptide--biological activity?
Insulin—a hormone critical for the control of blood glucose—is first synthesized as a longer prohormone. During its maturation, a peptide, C-peptide, is cleaved from the protein, but has been thought to be biologically inert. [HN2], [HN3] Defying the rule that peptide hormones act only by binding to stereospecific receptors, Ido et al. (1) report on page 563 of this issue that C-peptide not onl...
متن کاملMultirole Logic (Extended Abstract)
We identify multirole logic as a new form of logic in which conjunction/disjunction is interpreted as an ultrafilter on the power set of some underlying set (of roles) and the notion of negation is generalized to endomorphisms on this underlying set. We formalize both multirole logic (MRL) and linear multirole logic (LMRL) as natural generalizations of classical logic (CL) and classical linear ...
متن کاملProinsulin C-peptide - A Consensus Statement
In recent years the physiological role of the proinsulin C-peptide has received increasing attention, focusing on the potential therapeutic value of C-peptide replacement in preventing and ameliorating type 1 diabetic complications. In order to consolidate these new data and to identify the immediate directions of C-peptide research and its clinical usefulness, an International Symposium was he...
متن کاملThe Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model.
C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.
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ژورنال
عنوان ژورنال: Experimental Diabesity Research
سال: 2004
ISSN: 1543-8600,1543-8619
DOI: 10.1080/15438600490424389